Open Access Open Access  Restricted Access Subscription Access

ECO-FRIENDLY AND SUSTAINABLE SYNTHETIC APPROACHES TO BIOLOGICALLY SIGNIFICANT FUSED N-HETEROCYCLES

Shiv Shankar Gupta, Surekha Kumari, Inder Kumar, Upendra Sharma
Cover Image

Abstract


This review summarizes environmentally benign approaches for the synthesis of fused N-heterocycles since 2011. It is mainly focused on one-pot, multicomponent protocols for generating fused N-heterocyclic moieties with biological significance in atom-efficient manner. Several attractive and cost-effective approaches such as metal-, catalyst-, and solvent-free methods are discussed in this review. Electrochemical concept as green and environmentally optional strategy to produce fused N-heterocycles is also discussed. Synthesis of natural bioactive compounds like clausine V, glycoborine, and popular commercial drug alprazolam (Xanax) by utilizing such strategy is described.


Keywords


drug molecules; fused heterocycles; metal-free approach; multicomponent reactions.

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv