NOVEL VARIANTS OF THE MULTICOMPONENT REACTION FOR THE SYNTHESIS OF 1,2,4-TRIAZOLO[1,5-а]PYRIMIDINES AND PYRIDO[3,4-е][1,2,4]TRIAZOLO[1,5-а]PYRIMIDINES

Abstract

A new multicomponent reaction for regioselective synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidines using aminotriazoles, β-ketoglutaric acid dimethyl ester, and dimethylformamide dimethyl acetal was implemented. The selective reduction of 1,2,4-triazolo[1,5-a]pyrimidines to dihydro derivatives and the use of triazolo pyrimidines as starting compounds in multicomponent synthesis of dihydropyrido[3,4-е][1,2,4]triazolo[1,5-a]pyrimidinecarboxylates was demonstrated.