NOVEL VARIANTS OF THE MULTICOMPONENT REACTION FOR THE SYNTHESIS OF 1,2,4-TRIAZOLO[1,5-<i>а</i>]PYRIMIDINES AND PYRIDO[3,4-<i>е</i>][1,2,4]TRIAZOLO[1,5-<i>а</i>]PYRIMIDINES

Authors

  • Владимир А. Поликарчук Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Юлия В. Чертова Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Андрей Ю. Потапов Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Ирина В. Леденёва Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Евгения А. Кошелева Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Михаил Ю. Крысин Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Олег А. Козадёров Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Геннадий В. Шаталов Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Дмитрий Ю. Вандышев Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Хидмет С. Шихалиев Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Четти Прабхакар National Institute of Technology, Kurukshetra, Mirzapur Part, Haryana 136119, India

DOI:

https://doi.org/10.1007/5573

Keywords:

acetone-1, 3-dicarboxylates, aminotriazoles, dihydropyrido[3, 4-e]triazolo[1, 5-a]pyrimidines, dimethylformamide dimethyl acetal, 1, 2, 4-triazolo[1, high-resolution HPLC/MS, multicomponent reactions.

Abstract

A new multicomponent reaction for regioselective synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidines using aminotriazoles, β-ketoglutaric acid dimethyl ester, and dimethylformamide dimethyl acetal was implemented. The selective reduction of 1,2,4-triazolo[1,5-a]pyrimidines to dihydro derivatives and the use of triazolo pyrimidines as starting compounds in multicomponent synthesis of dihydropyrido[3,4-е][1,2,4]triazolo[1,5-a]pyrimidinecarboxylates was demonstrated.

Author Biographies

Владимир А. Поликарчук, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

аспирант кафедры органической химии

Юлия В. Чертова, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

студент кафедры органической химии

Андрей Ю. Потапов, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

доцент кафедры органической химии

Ирина В. Леденёва, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

старший научный сотрудник кафедры органической химии

Евгения А. Кошелева, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

научный сотрудник кафедры органической химии

Михаил Ю. Крысин, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

профессор кафедры органической химии

Олег А. Козадёров, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

профессор кафедры физической химии

Геннадий В. Шаталов, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

профессор кафедры химии высокомолекулярных соединий и коллоидов

Дмитрий Ю. Вандышев, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

доцент кафедры органической химии

Хидмет С. Шихалиев, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

заведующий кафедрой органической химии

Четти Прабхакар, National Institute of Technology, Kurukshetra, Mirzapur Part, Haryana 136119, India

профессор кафедры химии

Downloads

Published

2020-09-17

Issue

Vol. 56 No. 8 (2020)

Section

Original Papers