SYNTHESIS OF 2',3',4'-TRIARYL-5,6-DIHYDRO-8<i>H</i>-SPIRO[INDOLIZINE-7,5'-ISOXAZOLIDIN]-8-ONES <i>VIA</i> 1,3-DIPOLAR CYCLOADDITION REACTION INVOLVING (<i>Z</i>)-<i>C</i>-ARYL-<i>N</i>-PHENYLNITRONES

Authors

  • Youfeng Li School of Chemistry and Chemical Engineering, Zunyi Normal University, Zunyi Pingan Road, Zunyi 563006, China
  • Jin Tang Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan Taoyuan Road, Hunan 411201, China
  • Xiaofang Li Key Laboratory of Theoretical Organic Chemistry and Functional Molecules, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan Taoyuan Road, Hunan 411201, China

DOI:

https://doi.org/10.1007/5574

Keywords:

indolizine, isoxazolidine, nitrone, 1, 3-dipolar cycloaddition.

Abstract

The 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones to 7-arylmethylidene-6,7-dihydroindolizin-8(5H)-ones afforded novel 2',3',4'-triaryl-5,6-dihydro-8H-spiro[indolizine-7,5'-isoxazolidin]-8-ones in moderate yields. The structures of all the products were proved by NMR and IR spectroscopy, HRMS, and X-ray analysis.

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Published

2020-09-17

Issue

Vol. 56 No. 8 (2020)

Section

Original Papers