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SYNTHESIS OF 2',3',4'-TRIARYL-5,6-DIHYDRO-8H-SPIRO[INDOLIZINE-7,5'-ISOXAZOLIDIN]-8-ONES VIA 1,3-DIPOLAR CYCLOADDITION REACTION INVOLVING (Z)-C-ARYL-N-PHENYLNITRONES

Youfeng Li, Jin Tang, Xiaofang Li
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Abstract


The 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones to 7-arylmethylidene-6,7-dihydroindolizin-8(5H)-ones afforded novel 2',3',4'-triaryl-5,6-dihydro-8H-spiro[indolizine-7,5'-isoxazolidin]-8-ones in moderate yields. The structures of all the products were proved by NMR and IR spectroscopy, HRMS, and X-ray analysis.


Keywords


indolizine; isoxazolidine; nitrone; 1,3-dipolar cycloaddition.

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