

ENANTIOSELECTIVE SYNTHESIS OF 4,5-DISUBSTITUTED PYRROLIDIN-2-ONE DERIVATIVES WITH TWO STEREOCENTERS ON THE BASIS OF MICHAEL ADDUCTS

Abstract
The addition of malonates to trans-β-alkyl-β-nitrostyrenes in the presence of chiral Mg2+ bisoxazoline complex and Ni2+ and Co2+ bis((S,S)- or (R,R)-N,N'-dibenzylcyclohexane-1,2-diamine) complexes resulted in the formation of Michael adducts with two stereocenters which were used as key precursors for the preparation of potentially biologically active enantiopure 4,5-disubstituted pyrrolidin-2-one derivatives.
Keywords
chiral Mg2+, Ni2+, and Co2+ complexes; 4,5-disubstituted pyrrolidin-2-ones; Michael adduct; asymmetric catalysis
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv