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SYNTHESIS OF NOVEL TETRAHYDROPYRIMIDO[4,5-b][1,6]NAPHTHYRIDINES VIA CONDENSATION OF 1-BENZYL-3,5-BIS[(E)-ARYLMETHYLIDENE]TETRAHYDROPYRIDIN-4(1H)-ONES WITH 6-AMINOURACILS

Mehdi Ghandi, Rasoul Rashid, Alireza Abbasi
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Abstract


The successful synthesis of novel tetrahydropyrimido[4,5-b][1,6]naphthyridine derivatives is reported. 1-Benzyl-3,5-bis[(E)-arylmethylidene]tetrahydropyridin-4(1H)-ones prepared via Knoevenagel condensation of 1-benzyl-4-piperidinone with aromatic aldehydes undergo condensation with 6-aminouracils in acetic acid to afford the desired products. Structures of the products are confirmed by analytical data and X-ray crystallography analysis.


Keywords


6-aminouracils; 1-benzyl-4-piperidinone; 1,6-naphthyridines.

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