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INDOLE DERIVATIVES OF FUSIDANE TRITERPENOIDS: SYNTHESIS AND THE ANTIBACTERIAL ACTIVITY

Елена Е. Салимова, Айгуль А. Магафурова, Елена В. Третьякова, Ольга С. Куковинец, Людмила В. Парфенова
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Abstract


New indole derivatives of fusidic acid were synthesized by using the Fischer reaction. The obtained compounds were screened in vitro for antibacterial activity and were found to inhibit the growth of Staphylococcus aureus (MRSA, strain ATCC 43300) at concentrations comparable to fusidic acid. The obtained indole derivatives of fusidic acid were also characterized by relatively low cytotoxicity and minimal hemolytic effect at the highest concentration that was tested (32 μg/ml).

Keywords


indoles; fusidic acid; antibacterial activity; Fischer reaction.

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