

STRUCTURE AND ANTIBACTERIAL ACTIVITY (MEDIATED BY THE SOS RESPONSE) OF SPIROPIPERIDINIUM SALTS OBTAINED BY CYCLIZATION OF MANNICH BASES OF ARYLALIPHATIC 1,5-DIKETONES

Abstract
New derivatives of 3,5-dibenzoylspiropiperidinium salts were obtained by the previously developed method of cyclization of Mannich methylidene monobases of arylaliphatic 1,5-diketones and their antibacterial activity was studied. The structure of one of the salts was determined by X-ray structural analysis. The study of the mechanism of action using the pDualrep2 reporter system showed that some compounds cause the SOS response in the bacterial cell.
Keywords
1,5-diketones; Mannich bases; quaternary ammonium salts; spiropiperidinium salts; antibacterial activity; SOS response.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv