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STRUCTURE AND ANTIBACTERIAL ACTIVITY (MEDIATED BY THE SOS RESPONSE) OF SPIROPIPERIDINIUM SALTS OBTAINED BY CYCLIZATION OF MANNICH BASES OF ARYLALIPHATIC 1,5-DIKETONES

Алексей В. Букреев, Таисия И. Акимова, Илья А. Остерман, Анна Н. Шахтина, Юлия В. Худякова, Андрей В. Герасименко, Петр В. Сергиев, Ольга А. Донцова, Павел И. Дерябин, Вера Б. Колычева
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Abstract


New derivatives of 3,5-dibenzoylspiropiperidinium salts were obtained by the previously developed method of cyclization of Mannich methylidene monobases of arylaliphatic 1,5-diketones and their antibacterial activity was studied. The structure of one of the salts was determined by X-ray structural analysis. The study of the mechanism of action using the pDualrep2 reporter system showed that some compounds cause the SOS response in the bacterial cell.

Keywords


1,5-diketones; Mannich bases; quaternary ammonium salts; spiropiperidinium salts; antibacterial activity; SOS response.

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