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PARALLEL SYNTHESIS OF DERIVATIVES OF 1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDS WITH HETEROCYCLIC SUBSTITUENTS AT POSITION 5

Любовь Е. Гребенкина, Андрей В. Матвеев, Михаил В. Чудинов
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Abstract


A mild universal method for the synthesis of derivatives of 5-substituted 1H-1,2,4-triazole-3-carboxylic acids from a single precursor, ethyl β-N-Boc-oxalamidrazone, has been proposed. The method was applied for the parallel synthesis of a library of 1H-1,2,4-triazole-3-carboxamides with heterocyclic substituents at position 5.

Authors: Lyubov E. Grebenkina, Andrey V. Matveev*, Mikhail V. Chudinov


Keywords


β-N-Boc-oxalamidrazone; 1,2,4-triazole-3-carboxamide; 1,2,4-triazole-3-carboxylic acids; cyclization; parallel synthesis

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