Open Access Open Access  Restricted Access Subscription Access

THE SYNTHESIS OF NEW ACYCLIC ANALOGS OF 3-PHENACYLURIDINE AND COMPARATIVE EVALUATION OF THEIR IN VIVO BIOLOGICAL ACTIVITY

Иван А. Новаков, Лейла Л. Брунилина, Иван А. Кириллов, Максим Б. Навроцкий, Мария Д. Робинович, Евгения С. Титова, Дмитрий С. Шейкин, Евсей А. Ручко, Алла В. Павлова, Анастасия А. Котлярова, Татьяна Г. Толстикова
Cover Image

Abstract


New structural analogs of 3-phenacyluridine were obtained as a result of N(3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl)uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.

Keywords


3-phenacyluridine; alkylation; biological activity; hypnotics; uridine receptor.

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv