

THE SYNTHESIS OF NEW ACYCLIC ANALOGS OF 3-PHENACYLURIDINE AND COMPARATIVE EVALUATION OF THEIR IN VIVO BIOLOGICAL ACTIVITY

Abstract
New structural analogs of 3-phenacyluridine were obtained as a result of N(3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl)uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.
Keywords
3-phenacyluridine; alkylation; biological activity; hypnotics; uridine receptor.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv