SYNTHESIS OF IMIDAZO[2,1-<i>b</i>][1,3]THIAZOLES – POTENTIAL ANTICANCER AGENTS DERIVED FROM γ-BROMODIPNONES

Authors

  • Людмила М. Потиха Kyiv Taras Shevchenko National University, 64 Volodymyrska St., Kyiv 01033, Ukraine
  • Владимир С. Броварец V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, 1 Murmanska St., Kyiv 02000, Ukraine

DOI:

https://doi.org/10.1007/5647

Keywords:

2-aminothiazole, γ-bromodipnone, imidazo[2, 1-b]thiazole, antitumor activity.

Abstract

We propose a new method for assembling the imidazo[2,1-b][1,3]thiazole system, based on the reaction of (2Z)-1,3-diaryl-4-bromobut-2en-1-one derivatives with 2-aminothiazoles. The outcome of this reaction depends on the structure of the starting bromo ketone: when electron-withdrawing substituents are present in the structure of the ketone, a competing reaction occurs, which leads to the formation of 2,5-diarylfurans. Screening for antitumor activity has been performed in the case of 1-phenyl-2-(6-phenyl-5,6-dihydroimidazo[2,1-b]-thiazol-6-yl)ethanone and this compound has shown moderate ability to suppress the growth of kidney cancer cells, with a weaker effect on the cell lines of prostate cancer, colon cancer, and leukemia.

 

Author Biographies

Людмила М. Потиха, Kyiv Taras Shevchenko National University, 64 Volodymyrska St., Kyiv 01033, Ukraine

кафедра органической химии, заведующая научно-исследовательской лабораторией

Владимир С. Броварец, V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, 1 Murmanska St., Kyiv 02000, Ukraine

Руководитель отдела "Химия биоактивных азотсодержащих гетероциклических оснований"

Published

2020-09-17

Issue

Section

Original Papers