SPIRO DERIVATIVES OF 1,10b-DIHYDRO-5<i>H</i>-PYRAZOLO[1,5-<i>c</i>][1,3]BENZOXAZINES AND THEIR ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITY
Authors
Лидия З. Мандзюк
Ivano-Frankivsk National Medical University,
2 Halyt'ska St., Ivano-Frankivsk 76018, Ukraine
Василий С. Матийчук
Ivan Franko National University of Lviv
6 Kyryla i Mefodia St., Lviv, 79005, Ukraine
Тарас И. Чабан
Danylo Halytsky Lviv National Medical University,
69 Pekarska St., Lviv 79010, Ukraine
Олеся В. Боднарчук
Ivano-Frankivsk National Medical University,
2 Halyt'ska St., Ivano-Frankivsk 76018, Ukraine
Юлия Э. Матийчук
Danylo Halytsky Lviv National Medical University,
69 Pekarska St., Lviv 79010, Ukraine
Мыкола Д. Обушак
Ivan Franko National University of Lviv
6 Kyryla i Mefodia St., Lviv, 79005, Ukraine
The reaction of 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols with cyclopentanone, cyclohexanone, or 4-methylcyclohexanone gave spiro derivatives of 1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazines. The antimicrobial, anti-inflammatory, and antioxidant activities of these compounds were studied. A compound with a high antimicrobial activity against S. aureus ATCC 43300, together with compounds possessing an anti-inflammatory effect superior to the reference drug diclofenac, as well as high antioxidant activity, were identified.
Author Biographies
Лидия З. Мандзюк, Ivano-Frankivsk National Medical University,
2 Halyt'ska St., Ivano-Frankivsk 76018, Ukraine
Ассистент кафедры химиии
Василий С. Матийчук, Ivan Franko National University of Lviv
6 Kyryla i Mefodia St., Lviv, 79005, Ukraine
Профессор кафедрой органической химии
Тарас И. Чабан, Danylo Halytsky Lviv National Medical University,
69 Pekarska St., Lviv 79010, Ukraine
Доцент
Олеся В. Боднарчук, Ivano-Frankivsk National Medical University,
2 Halyt'ska St., Ivano-Frankivsk 76018, Ukraine
Доцент кафедры химиии
Юлия Э. Матийчук, Danylo Halytsky Lviv National Medical University,
69 Pekarska St., Lviv 79010, Ukraine
Инженер
Мыкола Д. Обушак, Ivan Franko National University of Lviv
6 Kyryla i Mefodia St., Lviv, 79005, Ukraine
