NUCLEOPHILIC SUBSTITUTION OF THE NITRO GROUP IN 1-SUBSTITUTED 3-NITRO-1 H -1,2,4-TRIAZOLES IN ETHANOLIC POTASSIUM HYDROXIDE

Ани Г. Асратян; Астхик А. Сукоян; Алексан Г. Шахатуни; Геворг Г. Данагулян; Оганес С. Аттарян

doi:10.1007/5659

NUCLEOPHILIC SUBSTITUTION OF THE NITRO GROUP IN 1-SUBSTITUTED 3-NITRO-1H-1,2,4-TRIAZOLES IN ETHANOLIC POTASSIUM HYDROXIDE

Ани Г. Асратян, Астхик А. Сукоян, Алексан Г. Шахатуни, Геворг Г. Данагулян, Оганес С. Аттарян

Abstract

Dehydrochlorination of 1-(2-chloroethyl)-3-nitro-1H-1,2,4-triazole in ethanolic potassium hydroxide is accompanied by nucleophilic substitution of the nitro group by the ethoxy group. The same nucleophilic exchange in 1-substituted 3-nitro-1H-1,2,4-triazoles occurs in methanol and n-propanol solutions of potassium hydroxide.

Keywords

1,2,4-triazole; dehydrochlorination; ethanolic solutions; nitro group; nucleophilic substitution.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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