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EFFICIENT SYNTHESIS OF IMIDAZOLE AND PYRIMIDINE DERIVATIVES

Oleksii O. Kolomoitsev, Eugene S. Gladkov, Volodymyr M. Kotlyar, Polina I. Pedan, Oleksandr V. Onipko, Oleksandr V. Buravov, Valentyn A. Chebanov
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Abstract


A convenient and affordable synthetic pathway for obtaining new α-aminoamidines starting from aminonitriles is proposed. The
α-aminoamidines obtained can be applied as substrates for further transformations and synthesis of imidazole- and pyrimidine-containing
building blocks.

Keywords


α-aminoamidine; 1-chloropropan-2-one; 3-(diethylamino)prop-2-enal; heterocycle; imidazole; pyrimidine.

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