SYNTHESIS AND EVALUATION OF THE CYTOTOXICITY OF INDENO[1,2-c]ISOQUINOLINE DERIVATIVES BEARING ESTER FUNCTIONAL GROUP AND 1,2,3-TRIAZOLE MOIETY

Abstract

Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC50) values in a range of 20–40 μM.