Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS AND EVALUATION OF THE CYTOTOXICITY OF INDENO[1,2-c]ISOQUINOLINE DERIVATIVES BEARING ESTER FUNCTIONAL GROUP AND 1,2,3-TRIAZOLE MOIETY

Hoai Thu Pham, Giang Le-Nhat-Thuy, Tuyet Thi Anh Dang, Phuong Thi Hoang, Tuan Anh Nguyen, Thanh Ha Nguyen, Tien Dung Nguyen, Hanh Thuong Ngo, Tuan Anh Le, Tuyen Van Nguyen
Cover Image

Abstract


Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC50) values in a range of 20–40 μM.


Keywords


indenoisoquinoline, 1,2,3-triazole, click chemistry, cytotoxicity, pharmacophore hybridization

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv