SYNTHESIS OF 1,2-DIHYDROISOQUINOLINE-1-CARBOXYLATES UNDER COBALT CATALYSIS

Authors

  • Paula Amanda Zagorska Latvian Institute of Organic Synthesis, Aizkraukles St. 21, Riga, LV-1006, Latvia
  • Liene Grigorjeva Latvian Institute of Organic Synthesis, Aizkraukles St. 21, Riga, LV-1006, Latvia
  • Jekaterina Bolsakova Latvian Institute of Organic Synthesis, Aizkraukles St. 21, Riga, LV-1006, Latvia

DOI:

https://doi.org/10.1007/5694

Keywords:

alkaloids, 1, 2-dihydroisoquinoline, heterocycles, isoquinoline, phenylglycine.

Abstract

A study of cobalt-catalyzed C–H functionalization of phenylglycine derivatives with alkynes is described. During the optimization studies, a range of cobalt catalysts, oxidants, base additives, and reaction solvents were evaluated. Product yield dependence on phenylglycine ester substituent was evaluated. Conditions for 1,2-dihydroisoquinoline synthesis with acceptable yield were found.

Author Biography

Paula Amanda Zagorska, Latvian Institute of Organic Synthesis, Aizkraukles St. 21, Riga, LV-1006, Latvia

Organic Synthesis Methodology Group, Principal Researcher

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Published

2021-02-22

Issue

Vol. 57 No. 2 (2021)

Section

Original Papers