SYNTHESIS OF 1,2-DIHYDROISOQUINOLINE-1-CARBOXYLATES UNDER COBALT CATALYSIS

Abstract

A study of cobalt-catalyzed C–H functionalization of phenylglycine derivatives with alkynes is described. During the optimization studies, a range of cobalt catalysts, oxidants, base additives, and reaction solvents were evaluated. Product yield dependence on phenylglycine ester substituent was evaluated. Conditions for 1,2-dihydroisoquinoline synthesis with acceptable yield were found.