Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF FLUORINATED OCTAHYDRO-2H-CHROMENES IN THE PRESENCE OF THE BF3•Et2O–H2O CATALYTIC SYSTEM

Ирина В. Ильина, Оксана С. Патрушева, Дина В. Корчагина, Константин П. Волчо, Нариман Ф. Салахутдинов
Cover Image

Abstract


The synthesis of fluorinated octahydro-2H-chromene was carried out using the Prins reaction between the monoterpenoid (–)-isopulegol and carbonyl compounds in the presence of the BF3·Et2O/H2O,system, which acts as both an acid catalyst and a fluorine source. The use of the readily available and easy-to-use BF3·OEt2 reagent makes this method of obtaining fluorine derivatives simple and practical.

Authors: Irina V. Il'ina, Oksana S. Patrusheva, Dina V. Korchagina, Konstantin P. Volcho*, Nariman F. Salakhutdinov


Keywords


acid catalysts; boron trifluoride etherate; chromene; isopulegol; monoterpenes; organofluorine compounds; Prins reaction

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv