

SYNTHESIS OF FLUORINATED OCTAHYDRO-2H-CHROMENES IN THE PRESENCE OF THE BF3•Et2O–H2O CATALYTIC SYSTEM

Abstract
The synthesis of fluorinated octahydro-2H-chromene was carried out using the Prins reaction between the monoterpenoid (–)-isopulegol and carbonyl compounds in the presence of the BF3·Et2O/H2O,system, which acts as both an acid catalyst and a fluorine source. The use of the readily available and easy-to-use BF3·OEt2 reagent makes this method of obtaining fluorine derivatives simple and practical.
Authors: Irina V. Il'ina, Oksana S. Patrusheva, Dina V. Korchagina, Konstantin P. Volcho*, Nariman F. Salakhutdinov
Keywords
acid catalysts; boron trifluoride etherate; chromene; isopulegol; monoterpenes; organofluorine compounds; Prins reaction
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv