SYNTHESIS OF FLUORINATED OCTAHYDRO-2H-CHROMENES IN THE PRESENCE OF THE BF3•Et2O–H2O CATALYTIC SYSTEM

Abstract

The synthesis of fluorinated octahydro-2H-chromene was carried out using the Prins reaction between the monoterpenoid (–)-isopulegol and carbonyl compounds in the presence of the BF₃·Et₂O/H₂O,system, which acts as both an acid catalyst and a fluorine source. The use of the readily available and easy-to-use BF₃·OEt₂ reagent makes this method of obtaining fluorine derivatives simple and practical.

Authors: Irina V. Il'ina, Oksana S. Patrusheva, Dina V. Korchagina, Konstantin P. Volcho*, Nariman F. Salakhutdinov