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ONE-POT PROPARGYLATION AND CLAISEN-TYPE REARRANGEMENT FOR NATURAL LIGNANS MATAIRESINOL AND α-CONIDENDRIN

Dmitry S. Ryabukhin, Lucas Lagerquist, Patrik Runeberg, Jani Rahkila, Patrik C. Eklund
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Abstract


Improved methods for one-pot propargylation and Claisen rearrangement have been devised for natural lignans – matairesinol and α-conidendrin. The rearrangement was regiospecific, yielding only 2-methylbenzofuran derivatives.

Keywords


benzofurans; lignans; propargyl ethers; superacids; Claisen rearrangement; natural compounds; propargylation

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