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RECYCLIZATION OF N-ARYLITACONIMIDES WITH CARBOXIMIDAMIDES – A NOVEL EFFICIENT METHOD FOR THE SYNTHESIS OF 2-(2-AMINO-6-OXO-1,4,5,6-TETRAHYDROPYRIMIDIN-5-YL)ACETANILIDES

Никита М. Сотников, Юрий А. Ковыгин, Дмитрий Ю. Вандышев, Ирина В. Леденёва, Евгения А. Кошелева, Олег А. Козадёров, Хидмет С. Шихалиев
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Abstract


A convenient method for the preparation of 2-(2-amino-6-oxo-1,4,5,6-tetrahydropyrimidin-5-yl)acetanilides based on the reaction of N-arylitaconimides with various carboximidamides has been proposed. In the course of the transformation, a cascade reaction occurs encompassing the aza-Michael addition of carboximidamides to N-arylitaconimides and the subsequent recyclization of intermediates to dihydropyrimidine acetanilides.

Keywords


carboximidamides; dihydropyrimidines; itaconimides; hybrid molecules; recyclization.

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