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SYNTHESIS AND STRUCTURE OF 2-ARYLAMINO-SUBSTITUTED 4-(DICHLOROMETHYLIDENE)-3-NITRO-4H-PYRIDO[1,2-a]PYRIMIDINES

Ирина А. Колесник, Сергей К. Петкевич, Петр В. Курман, Александр С. Ляхов, Людмила С. Ивашкевич, Хонгвэй Чжоу, Владимир И. Поткин
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Abstract


The reaction of 4-substituted anilines with 3,4,4-trichloro-1,1-bis(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-dienes led to 1-arylamino-3,4,4-trichloro-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-dienes, which under the action of 2-aminopyridines underwent heterocyclization to the corresponding 2-arylamino-substituted 4-(dichloromethylidene)-3-nitro-4H-pyrido[1,2-a]pyrimidines. The molecular structure of 4H-pyrido[1,2-a]pyrimidine containing the (4-ethoxyphenyl)amine substituent at position 2 was determined by X-ray structural analysis.


Keywords


arylamine, azole, nitrobutadiene, pyrido[1,2-a]pyrimidine, heterocyclization, nucleophilic substitution

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