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SYNTHETIC STRATEGIES FOR PYRROLO[2,1-f][1,2,4]TRIAZINE: THE PARENT MOIETY OF ANTIVIRAL DRUG REMDESIVIR

Gaurav S. Rai, Jayesh J. Maru
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Abstract


This review summarizes diverse synthetic protocols for the preparation of pyrrolo[2,1-f][1,2,4]triazine derivatives, covering literature sources from the past two decades. For effective representation, the synthetic methods toward the title compound are classified into six distinct categories: 1) synthesis from pyrrole derivatives, 2) synthesis via bromohydrazone, 3) synthesis via formation of triazinium dicyanomethylide, 4) multistep synthesis, 5) transition metal mediated synthesis, and 6) rearrangement of pyrrolooxadiazines. A brief outline of all optimized schemes is provided with relevant examples.

Keywords


pyrrolo[2,1-f][1,2,4]triazine; remdesivir; anti-norovirus activity; antiviral drug; COVID-19; kinase inhibitor.

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