GOOD PYRIDINE HUNTING: A BIOMIMIC COMPOUND, A MODIFIER AND A UNIQUE PHARMACOPHORE IN AGROCHEMICALS

Authors

  • Владимир В. Захарычев D. Mendeleyev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia
  • Александр В. Кузенков D. Mendeleyev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia
  • Андрей М. Марцынкевич National Centre for safety of aquatic fisheries products and aquaculture, 14-1 Grafskiy Pereulok, Moscow 129626, Russia

DOI:

https://doi.org/10.1007/5831

Keywords:

pyridine, agrochemicals, bioisosterism, fungicides, herbicides, insecticides, nematicides, plant protection, zoocides.

Abstract

95 agrochemical products have been described based on the pyridine scaffold making it the most commercially successful heterocycle in the synthesis of plant protection chemicals in the 21st century. The pyridine fragment is capable of modifying the properties of compounds, sometimes changing their application, and can be a unique pharmacophore. When possible, the relationship of pyridine analogs with carbocyclic or aliphatic precursors is shown. The mechanism of action of the compounds is described, if known. Examples of syntheses of pyridine intermediates used in the manufacture of agrochemicals are given.

 

Author Biographies

Владимир В. Захарычев, D. Mendeleyev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia

Кафедра химии и технологии органического синтеза, доцент

Александр В. Кузенков, D. Mendeleyev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia

Кафедра химии и технологии органического синтеза, доцент

Андрей М. Марцынкевич, National Centre for safety of aquatic fisheries products and aquaculture, 14-1 Grafskiy Pereulok, Moscow 129626, Russia

Испытательная референс-лаборатория, заведующий

Published

2020-12-18

Issue

Section

Review Articles