2-aminopyridine, γ-bromodipnone, imidazo[2, 1-a]pyridine, antitumor activity, Michael addition.
Abstract
2-Aryl-2-(2-aryl-2-oxoethyl)-1H,2H,3H-imidazo[1,2-a]pyridin-4-ium bromides were obtained in the reaction of (2Z)-4-bromo-1,3-diphenylbut-2-en-1-one derivatives with 2-aminopyridines in benzene. The effect of the structure of the starting reagents on the results of the reactions was studied. Antitumor activity of 2-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxoethyl]-1H,2H,3H-imidazo[1,2-a]pyridin-4-ium bromide was determined, which showed high antitumor potential of the test compound on 60 human cancer cell lines.
Author Biographies
Людмила М. Потиха, Taras Shevchenko National University of Kyiv,
64 Volodymyrska St., Kyiv 01033, Ukraine
Заведующая научно-исследовательской лабораторией, кафедра органической химии
Владимир С. Броварец, V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry,
1 Murmanska St., Kyiv 02094, Ukraine
