SILVER-ASSISTED PALLADIUM-CATALYZED ONE-POT SYNTHESIS OF 3-(HETERO)ARYLMETHYL DERIVATIVES OF IMIDAZO[1,2- a ]PYRIDINES

Krishna C. Kasina; Siva K. Rapeti; Arghya Sadhukhan; Mahesh Ranga; Arani Pal; Saritha Birudaraju; Siva r. Tirukkovalluri

doi:10.1007/5864

SILVER-ASSISTED PALLADIUM-CATALYZED ONE-POT SYNTHESIS OF 3-(HETERO)ARYLMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES

Krishna C. Kasina, Siva K. Rapeti, Arghya Sadhukhan, Mahesh Ranga, Arani Pal, Saritha Birudaraju, Siva r. Tirukkovalluri

Abstract

3-(Hetero)arylmethyl derivatives of imidazo[1,2-a]pyridine have been synthesized by a novel one-pot method consisting of the Sonogashira coupling of tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate with different substituted (hetero)aryl bromides and cyclization of the in situ obtained intermediate substituted (hetero)aryl acetylene derivatives.

Keywords

benzylimidazo[1,2-a]pyridine; C–C coupling; 5-exo-dig cyclization; metal-catalyzed reactions; one-pot synthesis.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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