Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF 1'-ARYL-3''-(1H-BENZOTRIAZOL-1-YL)-5',5'',6',6'',7',7a'-HEXAHYDRO-1'H,8''H-DISPIRO[INDENO[1,2-b]QUINOXALINE-11,3'-PYRROLIZINE-2',7''-INDOLIZIN]-8''-ONES via CYCLOADDITION REACTION

Yulin Ling, Yulin Huang, Xiaofang Li
Cover Image

Abstract


The 1,3-dipolar cycloaddition reaction of (E)-7-arylidene-3-(1H-benzotriazol-1-yl)-6,7-dihydroindolizin-8(5H)-one and azomethine ylide which was generated in situ by the reaction of 11H-indeno[1,2-b]quinoxalin-11-one and L-proline afforded novel 1'-aryl-3''-(1H-benzotriazol-1-yl)-5',5'',6',6'',7',7a'-hexahydro-1'H,8''H-dispiro[indeno[1,2-b]quinoxaline-11,3'-pyrrolizine-2',7''-indolizin]-8''-one in moderate yields. The structures of all the products were characterized thoroughly by NMR, IR spectra, HRMS together with X-ray crystallographic analysis.

Keywords


azomethine ylide; 11H-indeno[1,2-b]quinoxalin-11-one; L-proline; 1,3-dipolar cycloaddition.

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv