A THREE-COMPONENT CONDENSATION OF CYCLIC ENAMINO KETONES, PHENYLGLYOXAL HYDRATE, AND ETHYL CYANOACETATE

Authors

  • Александр Н. Андин Far Eastern Federal University, k. L Universitetsky Ave., Russky Island, Vladivostok 690922, Russia

DOI:

https://doi.org/10.1007/5960

Keywords:

ethyl cyanoacetate, 2, 3, 4, 5, 6, 7-hexahydroindoles, 7-tetrahydroindoles, phenylglyoxal, three-component condensation.

Abstract

A three-component condensation of cyclic enaminones, phenylglyoxal hydrate, and ethyl cyanoacetate in EtOH gave a number of 4,5,6,7-tetrahydroindole functional derivatives. The corresponding intermediates, 2,3,4,5,6,7-hexahydroindoles, are formed under mild conditions. Under more severe conditions (heating under reflux in DMF), cleavage of the ethoxycarbonyl group takes place.

Author Biography

Александр Н. Андин, Far Eastern Federal University, k. L Universitetsky Ave., Russky Island, Vladivostok 690922, Russia

Доцент кафедры органической химии

Published

2021-01-26

Issue

Section

Original Papers