

A NEW STRAIGHTFORWARD APPROACH TO 3-(ARYLIDENEAMINO)HYDANTOINS

Abstract
A novel straightforward approach to 3-(arylideneamino)hydantoins has been developed. It is based on the reaction of readily available 4-(tosylmethyl)semicarbazones with NaCN in DMF followed by heating of the obtained 4-(cyanomethyl)semicarbazones with concd HCl.
Keywords
3-(arylideneamino)hydantoins; α-(4-semicarbazono)nitriles; 4-(tosylmethyl)semicarbazones; α-amidoalkylation.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv