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A NEW STRAIGHTFORWARD APPROACH TO 3-(ARYLIDENEAMINO)HYDANTOINS

Alexander N. Yankov, Anatoly D. Shutalev
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Abstract


A novel straightforward approach to 3-(arylideneamino)hydantoins has been developed. It is based on the reaction of readily available 4-(tosylmethyl)semicarbazones with NaCN in DMF followed by heating of the obtained 4-(cyanomethyl)semicarbazones with concd HCl.

Keywords


3-(arylideneamino)hydantoins; α-(4-semicarbazono)nitriles; 4-(tosylmethyl)semicarbazones; α-amidoalkylation.

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