UNSATURATED CARBOXYLIC ACIDS IN THE ONE-POT SYNTHESIS OF NOVEL DERIVATIVES OF 3,4-DIHYDRO-2 H -THIOPYRAN

Екатерина А. Меркулова; Алексей В. Колобов; Константин Л. Овчинников; Виктор Н. Хрусталев; Валентин Г. Ненайденко

doi:10.1007/6020

UNSATURATED CARBOXYLIC ACIDS IN THE ONE-POT SYNTHESIS OF NOVEL DERIVATIVES OF 3,4-DIHYDRO-2H-THIOPYRAN

Екатерина А. Меркулова, Алексей В. Колобов, Константин Л. Овчинников, Виктор Н. Хрусталев, Валентин Г. Ненайденко

Abstract

The reactions of α,β-unsaturated ketones and Lawesson's reagent with maleic, itaconic, or 5-norbornene-2,3-dicarboxylic acid led to the corresponding 3,4-dihydro-2H-thiopyran anhydrides. As a result of the reaction of methacrylic acid, Lawesson's reagent, and chalcone, 4-methyl-1,8-diphenyl-2,6-dithiabicyclo[2.2.2]octan-3-one is formed. The selectivity of the acylation of amines using the synthesized anhydrides was studied.

Keywords

3,4-dihydro-2H-thiopyran; itaconic acid; Lawesson's reagent; maleic acid; acylation.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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