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4H-CHROMENES AS 1,3-BIELECTROPHILES IN THE REACTION WITH 2-AMINOBENZIMIDAZOLE: SYNTHESIS OF PYRIMIDO[1,2-a]BENZIMIDAZOLES

Виталий А. Осянин, Дмитрий В. Осипов, Кирилл С. Корженко, Олег П. Демидов, Юрий Н. Климочкин
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Abstract


A method for the preparation of pyrimido[1,2-a]benzimidazoles containing a 2-hydroxybenzyl or (2-hydroxynaphthalen-1-yl)methyl group at position 3 was proposed based on the reaction of β-carbonyl-substituted 4H-chromenes and their benzo analogs with 2aminobenzimidazole. In the case of chromenes substituted in the methylene fragment, 7,13a-dihydro-5H-benzo[5',6']chromeno-[3',2':5,6]pyrimido[1,2-a]benzimidazoles were isolated.

 


Keywords


2-aminobenzimidazole; β-carbonyl-substituted 1H-benzo[f]chromenes; 4H-chromenes; pyrimido[1,2-a]benzimidazoles; aza-Michael reaction; [3+3] cyclocondensation.

Full Text: PDF (Russian) Supplementary File(s): Supplementary information (260KB)


 

 

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