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METHODS OF SYNTHESIS AND ANTIVIRAL ACTIVITY OF NEW 4-ALKYL-3-NITRO-1,4-DIHYDROAZOLO[5,1-с][1,2,4]TRIAZIN-4-OLS

Роман А. Дрокин, Дмитрий В. Тюфяков, Егор К. Воинков, Павел А. Слепухин, Евгений Н. Уломский, Яна Л. Есаулкова, Александрина С. Волобуева, Кристина С. Ланцева, Мария А. Мисюрина, Владимир В. Зарубаев, Владимир Л. Русинов
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Abstract


An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Keywords


3-nitroazolo[5,1-с][1,2,4]triazines; α-nitro ketones; triazines; antiviral activity; Coxsackie B3 virus; influenza virus.

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