SYNTHESIS AND ANTIHERPETIC ACTIVITY OF NOVEL PURINE CONJUGATES WITH 7,8-DIFLUORO-3-METHYL-3,4-DIHYDRO-2 H -1,4-BENZOXAZINE

Ольга А. Воздвиженская; Валерия Л. Андронова; Георгий А. Галегов; Галина Л. Левит; Виктор П. Краснов; Валерий Н. Чарушин

doi:10.1007/6033

SYNTHESIS AND ANTIHERPETIC ACTIVITY OF NOVEL PURINE CONJUGATES WITH 7,8-DIFLUORO-3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE

Ольга А. Воздвиженская, Валерия Л. Андронова, Георгий А. Галегов, Галина Л. Левит, Виктор П. Краснов, Валерий Н. Чарушин

Abstract

A method for the synthesis of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine containing fragments of ω-amino acids with different lengths of the polymethylene chain as a linker has been developed. It was found in experiments in vitro that the obtained compounds are active against the herpes simplex virus type 1, including the acyclovir-resistant strain.

Keywords

ω-amino acids; 6-chloropurine; 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine; antiviral activity; herpes simplex virus type 1.

Full Text: PDF (Russian) Open Access

Supplementary File(s): None

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv

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