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ALKALOID-LIKE ANNULATED PYRANO[4,3-b]PYRROLES: ANTIVIRAL ACTIVITY AND HYDROLYSIS

Екатерина Е. Храмцова, Максим В. Дмитриев, Николай И. Бормотов, Ольга А. Серова, Лариса Н. Шишкина, Андрей Н. Масливец
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Abstract


Alkaloid-like angular 6/6/5/6-annulated pyrano[4,3-b]pyrroles (pretazettine analogs) contain chemically labile groups that can react with water at room temperature. Their antiviral activity against Vaccinia virus and their tendency to hydrolysis were investigated. Compounds that were more resistant to hydrolysis exhibited the greatest antiviral activity.

Keywords


pyrano[4,3-b]pyrroles; antiviral activity; hetero-Diels–Alder reaction; hydrolysis; orthopoxviruses.

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