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SYNTHESIS OF NOVEL 3-(PYRIDIN-4-YL)-1,2,4-TRIAZINES, THEIR ANALOGS AND STUDY OF THE ACTIVITY AGAINST VACCINIA VIRUS

Ольга В. Шабунина, Ярослав К. Штайц, Дмитрий С. Копчук, Алексей П. Криночкин, Сагата Сантра, Григорий В. Зырянов, Жуо Ванг, Владимир Л. Русинов, Олег Н. Чупахин
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Abstract


Using atom-economical approaches, new representatives of 3-(pyridin-4-yl)-1,2,4-triazines and their 4-nitrophenyl analogs were obtained, and their activity in relation to the vaccinia virus was studied. The new compounds have shown promising characteristics, in particular, in comparison to the antiviral drug Cidofovir.


Keywords


1,2,4-triazines; antiviral activity; ipso substitution; nucleophilic hydrogen substitution; solvent-free reactions; vaccinia virus.

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