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FREE-RADICAL AND ELECTROPHILIC FUNCTIONALIZATION OF PYRAZOL-3-ONES WITH C–O OR C–N BOND FORMATION
Abstract
Pyrazol-3-ones are known as a class of anti-inflammatory drugs and popular
heterocycles in search for new bioactive substances. The electrophilic or free-radical functionalization of C-4 position of pyrazolin-3-ones with the formation of C–C, C–S, C–Hal, C–N, and C–O bonds has been extensively developed in the last decade. Among these methods, the C–O or C–N bond forming reactions are studied less. This microreview covers selected examples of such reactions published in the last 10 years.
heterocycles in search for new bioactive substances. The electrophilic or free-radical functionalization of C-4 position of pyrazolin-3-ones with the formation of C–C, C–S, C–Hal, C–N, and C–O bonds has been extensively developed in the last decade. Among these methods, the C–O or C–N bond forming reactions are studied less. This microreview covers selected examples of such reactions published in the last 10 years.
Keywords
Pyrazolones; pyrazol-3-ones; free redicals; C-O coupling; C-N coupling
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv