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SYNTHESIS AND ANTIVIRAL ACTIVITY OF NONANNULATED TETRAZOLYLPYRIMIDINES

Владимир А. Островский, Геворг Г. Данагулян, Ольга М. Нестерова, Юлия Н. Павлюкова, Владимир В. Толстяков, Ольга С. Зарубина, Павел А. Слепухин, Яна Л. Есаулкова, Анна А. Мурылева, Владимир В. Зарубаев, Ростислав Е. Трифонов
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Abstract


Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.

Keywords


pyrimidines; tetrazoles; biological activity; linkers; properties; structure; synthesis.

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