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ANTIVIRAL DRUG TRIAZAVIRIN, SELECTIVELY LABELED WITH 2H, 13C, AND 15N STABLE ISOTOPES. SYNTHESIS AND PROPERTIES

Татьяна С. Шестакова, Сергей Л. Деев, Игорь А. Халымбаджа, Владимир Л. Русинов, Александр С. Парамонов, Александр С. Арсеньев, Захар О. Шенкарев, Валерий Н. Чарушин, Олег Н. Чупахин
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Abstract


Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy.

Keywords


azoloazines; antiviral activity; NMR spectroscopy; spin-spin coupling constants; stable isotopes.

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