

ANTIVIRAL DRUG TRIAZAVIRIN, SELECTIVELY LABELED WITH 2H, 13C, AND 15N STABLE ISOTOPES. SYNTHESIS AND PROPERTIES

Abstract
Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy.
Keywords
azoloazines; antiviral activity; NMR spectroscopy; spin-spin coupling constants; stable isotopes.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv