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3-CYANOAZOLO[5,1-c][1,2,4]TRIAZINES: SYNTHESIS AND ANTIVIRAL ACTIVITY

Ирина М. Сапожникова, Евгений Н. Уломский, Владимир Л. Русинов, Олег Н. Чупахин, Александр В. Степанов, Татьяна Н. Саватеева-Любимова, Константин В. Сивак
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Abstract


A series of azolo[5,1-c][1,2,4]triazines containing a cyano group were prepared as analogs of the drug Triazavirin (riamilovir). Sodium 3-cyano-7-methylsulfanyl-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-1-ide was tested for antiviral activity against the viruses of tickborne encephalitis, Venezuelan equine encephalomyelitis, and the Eastern equine encephalomyelitis using porcine embryonic kidney cell model and mouse model according to the emergency prophylaxis model and therapy model. The general toxicity of this compound was also characterized.

Keywords


azoloazines; azolotriazines; nitriles; antiviral activity; Eastern equine encephalomyelitis; tick-borne encephalitis; Venezuelan equine encephalomyelitis.

Full Text: PDF (Russian) Supplementary File(s): Supplementary information (649KB)


 

 

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