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ELECTROCATALYTIC CASCADE APPROACH TO THE SYNTHESIS OF DIHYDRO-2'H,3H-SPIRO[1-BENZOFURAN-2,5'-PYRIMIDINES]

Fedor V. Ryzhkov, Michail N. Elinson, Yuliya E. Ryzhkova, Anatoly N. Vereshchagin, Artem N. Fakhrutdinov, Mikhail P. Egorov
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Abstract


Electrocatalytic cascade assembly of benzylidenebarbiturates and cyclohexane-1,3-diones in methanol in the presence of sodium bromide as mediator in an undivided cell results in the formation of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines] in 72–85% yields. This electrochemical process occurs under mild conditions, and the isolation procedure after the reaction is simple. The structures of the final compounds were confirmed by 1H–13C HMBC spectroscopy.


Keywords


benzylidenebarbiturates; cyclohexane-1,3-diones; spiro[1-benzofuran-2,5'-pyrimidines]; cascade reactions; electrocatalysis.

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