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FEATURES OF THE REACTION OF 1-AMINO-2-NITROGUANIDINE WITH ISATINS. SYNTHESIS OF [1,2,4]TRIAZINO[5,6-b]INDOLES

Татьяна П. Ефимова, Мария П. Иванова, Тамара А. Новикова, Сергей В. Макаренко
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Abstract


Reactions of 1-amino-2-nitroguanidine with isatins leading to the formation of new β-(2-nitro)guanidinohydrazones of isatin, which exist as E/Z-isomers in regards to the azomethine fragment, were studied. It was found that the conditions of the reactions of 1-amino-2nitroguanidine with isatins affect the geometry of the formed hydrazones. Conditions for the cyclization of the obtained (Z)-β-(2-nitro)guanidinohydrazones leading to 3-nitroimino-containing [1,2,4]triazino[5,6-b]indoles were proposed.

 


Keywords


1-amino-2-nitroguanidine; isatin; isatin β-derivatives; 1,2,4-triazines; triazinoindoles; E/Z isomerism.

Full Text: PDF (Russian) Supplementary File(s): Supplementary information (2MB)


 

 

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