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SYNTHESIS OF 5-AZOLYL-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONES AND 5-AZOLYL-1,3,4-THIADIAZOL-2-AMINES BASED ON DERIVATIVES OF 5-ARYLISOXAZOLE-3-CARBOXYLIC AND 4,5-DICHLOROISOTHIAZOLE-3-CARBOXYLIC ACIDS

Сергей K. Петкевич, Нелия A. Жуковская, Евгений A. Дикусар, Екатерина A. Акишина, Петр B. Курман, Евгения B. Никитина, Владимир П. Зайцев, Владимир И. Поткин
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Abstract


2-Mercapto-1,3,4-triazoles and 2-amino-1,3,4-thiadiazoles were synthesized by successive transformations of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids and their derivatives. The amino group of 5-(4,5-dichloroisothiazol-3-yl)-1,3,4-thiadiazol-2-amine was acylated with 5-phenylisoxazole-3-carboxylic acid chloride. Simple approaches to the preparation of previously unknown heterocyclic assemblies containing two or three azole rings with a high potential for biological activity are described.

 


Keywords


isothiazole, isoxazole, thiadiazoles, thiosemicarbazides, triazoles, heterocyclization.

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