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SYNTHESIS OF 3(5)-ARYL-5(3)-PYRAZOLYL-1,2,4-OXADIAZOLE NITRO DERIVATIVES

Татьяна К. Шкинева, Ирина А. Вацадзе, Тигран Э. Хоранян, Димитрий Л. Липилин, Алла Н. Пивкина, Игорь Л. Далингер
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Abstract


A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl-O-acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.

Authors: Tatyana K. Shkineva, Irina A. Vatsadze, Tigran E. Khoranyan, Dmitry L. Lipilin, Alla N. Pivkina, Igor L. Dalinger*


Keywords


arylpyrazolyl-1,2,4-oxadiazole; nitropyrazole; 1,2,4-oxadiazole; cyclization; nitration; nucleophilic substitution; thermal stability

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