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SELENOPHENOCHROMONES SELECTIVELY INHIBIT HUMAN LUNG CARCINOMA CELLS GROWTH

Jelena Vasiljeva, Ilona Domracheva, Pavel Arsenyan
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Abstract


Synthetic procedures for the preparation of selenophenochromones by treating ethynyl chromones with selenium halides were elaborated.
Methyl 3-bromo-2-(1-hydroxycyclohexyl)-9-oxo-9H-selenopheno[2,3-f]chromene-7-carboxylate exhibits high selective in vitro cytotoxic
activity against human lung carcinoma cells A549 and H69 up to 1.2 μM.

Keywords


chromones; selenium; selenophenochromone; cytotoxicity

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