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METHODS FOR THE PREPARATION OF 3-NITROBENZOFURANS

Виталий А. Осянин, Дмитрий В. Осипов, Дарья А. Ращепкина, Юрий Н. Климочкин
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Abstract


The review summarizes the existing methods for the synthesis of 3-nitrobenzofurans and their polycondensed derivatives which are valuable substrates for dearomatization of the furan ring. The main attention is paid to the electrophilic nitration of 3-unsubstituted benzofurans and the preparation of 5-amino- and 5-hydroxy-3-nitrobenzofurans via the Nenitzescu indole synthesis from quinones or quinone monoimines and β-nitroenamines.

Keywords


3-nitrobenzofurans; β-nitroenamines; quinones; dearomatization; Nenitzescu reaction; nitration.

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