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SYNTHESIS AND PERMETHYLATION OF METHYL 5-(2-CHLOROPYRIDIN-3-YL)PENTANOATES

Franziska Bendrath, Peter Langer
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Abstract


Two methyl 5-(2-chloropyridin-3-yl)pentanoates were prepared by condensation of 1,3-bis(silyloxy)-1,3-butadienes with 2-chloropyridine-3-carboxylic acid chloride. The permethylation of the products resulted in two completely different products, depending on the substitution pattern of the 1,3,5-tricarbonyl moiety.


Keywords


8-azachromones; pyrano[2,3-b]pyridines; pyridines; silyl enol ethers; cyclizations.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv