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RECENT DEVELOPMENTS IN THE SYNTHESIS OF PIPERAZINES

Seyed Sajad Sajadikhah, Mahmoud Nassiri
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Abstract


The microreview focuses on the recent methods for the synthesis of piperazine derivatives, published in 2015–2020. The methods include cyclization of 1,2-diamine derivatives with sulfonium salts, the Ugi reaction, ring opening of aziridines under the action of N-nucleophiles, intermolecular cycloaddition of alkynes bearing amino group, parallel solid-phase synthesis, and photocatalytic synthesis.

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