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PYRAZOLES, ISOXAZOLES, AND 1,2,3-TRIAZOLES AS ANALOGS OF THE NATURAL CYTOSTATIC COMBRETASTATIN A-4: EFFICIENT ROUTES OF SYNTHESIS, TUBULIN INHIBITION, AND CYTOTOXICITY

Роман К. Костин, Александр С. Маршавин
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Abstract


The review discusses the advantages and disadvantages of combretastatin A-4, presents the most effective methods for the synthesis of its 1,2,3-triazole, pyrazole, isoxazole analogs. The structural formulas of the analogs of combretastatin A-4 which are the most active against cancer cells, together with indicators of cytotoxicity, are also presented.

 


Keywords


combretastatin A-4; combretastatin analogs; 3,5-diarylisoxazole; heterocycles; pyrazole; pyrazoline; 1,2,3-triazole; tubulin; cytotoxicity; tubulin-binding agents.

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