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LEWIS ACID CATALYZED CONDENSATION OF 2-AMINOHETARENE N-OXIDES WITH N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL

Сергей А. Каралаш, Дмитрий М. Быстров, Иван В. Ананьев, Леонид Л. Ферштат
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Abstract


A method for the introduction of the N,N-dimethylformamidine protective group in a series of six-membered 2-aminohetarene N-oxides was developed. It was shown that 2-amino derivatives of N-oxides of various six-membered heterocycles (pyridines, pyrimidines, pyrazines, tetrazines) successfully enter the reaction. The stability of the N,N-dimethylformamidine protecting group in 2-aminohetarene N-oxides was found to depend on the type of reaction medium.

 


Keywords


azines; heterocyclic N-oxides; Lewis acids; nitrogen-containing heterocycles; pyridines; condensation; protective groups.

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