SYNTHESIS OF 3-SUBSTITUTED TETRAHYDROINDOL-4-ONE

Abstract

A series of functionalized 4,5,6,7-tetrahydroindol-4-one derivatives containing a residue derived from β-dicarbonyl compound at  position 3 were prepared by a reaction of cyclic enaminones, arylglyoxal hydrates, and β-dicarbonyl compounds. Modification of acetyl-acetone residue at position 3 of tetrahydroindoles was accomplished by condensation with 1,2- and 1,4-bisnucleophiles.