AN EFFICIENT ONE-POT SYNTHESIS OF INDOLYL-4<i>H</i>-CHROMENE DERIVATIVES

Authors

  • Muralimohan Gampa Department of Chemistry, School of Science, Gitam University, Rudraram, Hyderabad, Telangana 502329, India
  • Pannala Padmaja Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Telanagana 500007, India
  • Seema Aravind Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, India
  • Pedavenkatagari Narayana Reddy Department of Chemistry, School of Science, Gitam University, Rudraram, Hyderabad, Telangana 502329, India

DOI:

https://doi.org/10.1007/6437

Keywords:

indoles, indolyl-4H-chromenes, (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine, salicylaldehydes.

Abstract

A new one-pot three-component reaction for the synthesis of indolyl-4H-chromene derivatives has been developed. The synthesis was achieved by reacting salicylaldehydes, (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine, and indoles in the absence of solvent using triethylamine as a catalyst. The final products were isolated by precipitation after the addition of ethanol to the reaction mixture. This transformation involves the formation of indole-substituted chromene ring by creation of two C–C bonds and one C–O bond in a single synthetic operation. This rapid one-pot reaction does not require chromatographic purification and provides the indolyl-4H-chromene derivatives in good yields.

Published

2021-12-15

Issue

Section

Original Papers