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ONE-POT SYNTHESIS OF 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLES CONTAINING AN ALKENYL MOIETY

Bepa В. Сиднева, Марина В. Тарасенко, Евгений Р. Кофанов
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Abstract


A one-pot method was developed for the preparation of 3,5-disubstituted 1,2,4-oxadiazoles containing an alkenyl fragment, which entails the preparation of O-acylamidoximes and their subsequent cyclization using N,N'-dimethylacetamide as a solvent. The proposed method allows to significantly reduce the overall synthesis time by carrying out all steps sequentially in a single reactor, avoiding the step of isolation of the intermediate O-acylamidoxime, leading to the production of 5-alkenyl-1,2,4-oxadiazoles in high yields.

 


Keywords


alkenyl aromatic carboxylic acids; 5-alkenyl-1,2,4-oxadiazoles; amidoximes; 3,5-disubstituted 1,2,4-oxadiazoles; O-acylation; cyclodehydration; one-pot synthesis.

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