INVESTIGATION OF THE REACTION OF 1-ADAMANTYL BROMOMETHYL KETONE WITH AZOLES

Abstract

The reactions of 1-adamantyl bromomethyl ketone with 1,2,4-triazole, benzotriazole, benzimidazole, 5-aminotetrazole, and 3(5)-amino-1,2,4-triazole were investigated, and the respective N-alkylation products were obtained. The optimum conditions were determined for alkylation in the presence of sodium hydride in hexamethylphosphorotriamide.

Authors: A. A. Danilin, P. P. Purygin, N. V. Makarova, and I. K. Moiseev.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (6), pp 674-676

http://link.springer.com/article/10.1007/BF02251625